Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

BACKGROUND: Pharmacokinetic interactions between rifampicin and protease inhibitors (PIs) complicate the management of HIV-associated tuberculosis. Rifabutin is an alternative rifamycin, for patients requiring PIs. Recently some international guidelines have recommended a higher dose of rifabutin (1...

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Pubblicato in:BMC Pharmacol Toxicol
Autori principali: Naiker, Suhashni, Connolly, Cathy, Wiesner, Lubbe, Kellerman, Tracey, Reddy, Tarylee, Harries, Anthony, McIlleron, Helen, Lienhardt, Christian, Pym, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277828/
https://ncbi.nlm.nih.gov/pubmed/25406657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-61
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