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Testing non-inferiority of a new treatment in three-arm clinical trials with binary endpoints
BACKGROUND: A two-arm non-inferiority trial without a placebo is usually adopted to demonstrate that an experimental treatment is not worse than a reference treatment by a small pre-specified non-inferiority margin due to ethical concerns. Selection of the non-inferiority margin and establishment of...
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| Publicado no: | BMC Med Res Methodol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4277823/ https://ncbi.nlm.nih.gov/pubmed/25524326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-14-134 |
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