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Immune aging and autoimmunity

Age is an important risk for autoimmunity, and many autoimmune diseases preferentially occur in the second half of adulthood when immune competence has declined and thymic T cell generation has ceased. Many tolerance checkpoints have to fail for an autoimmune disease to develop, and several of those...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Goronzy, Jörg J., Weyand, Cornelia M.
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277694/
https://ncbi.nlm.nih.gov/pubmed/22466672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-0970-0
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