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The Evolution of Heterogeneities Altered by Mutational Robustness, Gene Expression Noise and Bottlenecks in Gene Regulatory Networks

Intra-population heterogeneity is commonly observed in natural and cellular populations and has profound influence on their evolution. For example, intra-tumor heterogeneity is prevalent in most tumor types and can result in the failure of tumor therapy. However, the evolutionary process of heteroge...

詳細記述

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書誌詳細
出版年:PLoS One
第一著者: Zhang, Zhihua
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277480/
https://ncbi.nlm.nih.gov/pubmed/25541720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116167
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