An Integrative Analysis of PIK3CA Mutation, PTEN, and INPP4B Expression in Terms of Trastuzumab Efficacy in HER2-Positive Breast Cancer

The phosphoinositide-3-kinase (PI3K) pathway is commonly deregulated in breast cancer through several mechanisms, including PIK3CA mutation and loss of phosphatase and tensin homolog (PTEN) and inositol polyphosphate 4-phosphatase-II (INPP4B). We aimed to evaluate the predictive relevance of these b...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Sueta, Aiko, Yamamoto, Yutaka, Yamamoto-Ibusuki, Mutsuko, Hayashi, Mitsuhiro, Takeshita, Takashi, Yamamoto, Satoko, Iwase, Hirotaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277449/
https://ncbi.nlm.nih.gov/pubmed/25542038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116054
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