6,7-di-O-acetylsinococuline (FK-3000) induces G(2)/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation

We evaluated the cytostatic effect of 6,7-di-O-acetylsinococuline (FK-3000) isolated from Stephania delavayi Diels. against breast carcinoma cell lines MDA-MB-231 and MCF-7. FK-3000 suppressed CDC25B phosphorylation directly and indirectly via p38 MAPK phosphorylation. CDC25B dephosphorylation decre...

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Detalhes bibliográficos
Publicado no:Int J Oncol
Main Authors: LI, YONG-CHUN, KIM, BONG-HEE, CHO, SOON-CHANG, BANG, MI-AE, KIM, SUNMIN, PARK, DAE-HUN
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277248/
https://ncbi.nlm.nih.gov/pubmed/25384584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2739
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