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PCSK9 Antibodies for the Treatment of Hypercholesterolemia
The serine protease proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein (LDL) receptor (LDLR) and directs it to lysosomes for intracellular degradation. This results in decreased numbers of LDLR available on the hepatic cell surface to bind LDL particles and re...
Enregistré dans:
| Publié dans: | Nutrients |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276981/ https://ncbi.nlm.nih.gov/pubmed/25470376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu6125517 |
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