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Modulation of the Mevalonate Pathway by Akt Regulates Macrophage Survival and Development of Pulmonary Fibrosis

Protein kinase B (Akt) is a key effector of multiple cellular processes, including cell survival. Akt, a serine/threonine kinase, is known to increase cell survival by regulation of the intrinsic pathway for apoptosis. In this study, we found that Akt modulated the mevalonate pathway, which is also...

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Publicado en:J Biol Chem
Autores principales: Larson-Casey, Jennifer L., Murthy, Shubha, Ryan, Alan J., Carter, A. Brent
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276883/
https://ncbi.nlm.nih.gov/pubmed/25378391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593285
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