Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis

Genetic mutations in osteoclastogenic genes are closely associated with osteopetrotic bone diseases. Genetic defects in OSTM1 (osteopetrosis-associated transmembrane protein 1) cause autosomal recessive osteopetrosis in humans. In particular, OSTM1 mutations that exclude the transmembrane domain mig...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Shin, Bongjin, Yu, Jungeun, Park, Eui-Soon, Choi, Seunga, Yu, Jiyeon, Hwang, Jung Me, Yun, Hyeongseok, Chung, Young-Ho, Hong, Kwan Soo, Choi, Jong-Soon, Takami, Masamichi, Rho, Jaerang
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276856/
https://ncbi.nlm.nih.gov/pubmed/25359771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589614
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