Asymmetrical Macromolecular Complex Formation of Lysophosphatidic Acid Receptor 2 (LPA(2)) Mediates Gradient Sensing in Fibroblasts

Chemotactic migration of fibroblasts toward growth factors relies on their capacity to sense minute extracellular gradients and respond to spatially confined receptor-mediated signals. Currently, mechanisms underlying the gradient sensing of fibroblasts remain poorly understood. Using single-particl...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Ren, Aixia, Moon, Changsuk, Zhang, Weiqiang, Sinha, Chandrima, Yarlagadda, Sunitha, Arora, Kavisha, Wang, Xusheng, Yue, Junming, Parthasarathi, Kaushik, Heil-Chapdelaine, Rick, Tigyi, Gabor, Naren, Anjaparavanda P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276845/
https://ncbi.nlm.nih.gov/pubmed/25542932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595512
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