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LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS

Large case/control genome-wide association studies (GWAS) often include groups of related individuals with known relationships. When testing for associations at a given locus, current methods incorporate only the familial relationships between individuals. Here, we introduce the chromosome-based Qua...

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Detalhes bibliográficos
Publicado no:Ann Appl Stat
Main Authors: Sampson, Joshua N, Wheeler, Bill, Li, Peng, Shi, Jianxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275846/
https://ncbi.nlm.nih.gov/pubmed/25544865
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