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Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77.

Engagement of T-cell receptors (TCRs) on immature thymocytes by self-antigen-major histocompatibility complexes causes the death of self-reactive thymocytes via apoptosis, a phenomenon that establishes T-cell tolerance. Similarly, treatment of thymocytes with anti-TCR antibodies leads to TCR-mediate...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yazdanbakhsh, K, Choi, J W, Li, Y, Lau, L F, Choi, Y
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42755/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7831306/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.2.437
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