The IRF5–TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5–TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved...

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Publicado en:Hum Mol Genet
Main Authors: Kottyan, Leah C., Zoller, Erin E., Bene, Jessica, Lu, Xiaoming, Kelly, Jennifer A., Rupert, Andrew M., Lessard, Christopher J., Vaughn, Samuel E., Marion, Miranda, Weirauch, Matthew T., Namjou, Bahram, Adler, Adam, Rasmussen, Astrid, Glenn, Stuart, Montgomery, Courtney G., Hirschfield, Gideon M., Xie, Gang, Coltescu, Catalina, Amos, Chris, Li, He, Ice, John A., Nath, Swapan K., Mariette, Xavier, Bowman, Simon, Rischmueller, Maureen, Lester, Sue, Brun, Johan G., Gøransson, Lasse G., Harboe, Erna, Omdal, Roald, Cunninghame-Graham, Deborah S., Vyse, Tim, Miceli-Richard, Corinne, Brennan, Michael T., Lessard, James A., Wahren-Herlenius, Marie, Kvarnström, Marika, Illei, Gabor G., Witte, Torsten, Jonsson, Roland, Eriksson, Per, Nordmark, Gunnel, Ng, Wan-Fai, Anaya, Juan-Manuel, Rhodus, Nelson L., Segal, Barbara M., Merrill, Joan T., James, Judith A., Guthridge, Joel M., Hal Scofield, R., Alarcon-Riquelme, Marta, Bae, Sang-Cheol, Boackle, Susan A., Criswell, Lindsey A., Gilkeson, Gary, Kamen, Diane L., Jacob, Chaim O., Kimberly, Robert, Brown, Elizabeth, Edberg, Jeffrey, Alarcón, Graciela S., Reveille, John D., Vilá, Luis M., Petri, Michelle, Ramsey-Goldman, Rosalind, Freedman, Barry I., Niewold, Timothy, Stevens, Anne M., Tsao, Betty P., Ying, Jun, Mayes, Maureen D., Gorlova, Olga Y., Wakeland, Ward, Radstake, Timothy, Martin, Ezequiel, Martin, Javier, Siminovitch, Katherine, Moser Sivils, Kathy L., Gaffney, Patrick M., Langefeld, Carl D., Harley, John B., Kaufman, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Association Studies Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275071/
https://ncbi.nlm.nih.gov/pubmed/25205108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu455
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