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IL-18 is required for self-reactive T cell expansion in NOD mice
IL-18 has a well-established role in pro-inflammatory responses in the islets in type 1 diabetes. Here, we identify a distinctive role for IL-18 in expanding pathogenic T cells in the periphery of NOD mice. Well in advance of disease onset, the periphery of IL-18-deficient mice exhibits reduced T ce...
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| Publicado no: | J Autoimmun |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4275030/ https://ncbi.nlm.nih.gov/pubmed/21414755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2011.02.005 |
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