Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults

Loss-of-function mutations affecting the cholesterol transporter ATP-binding cassette transporter subfamily A member 1 (ABCA1) impair cellular cholesterol efflux and are associated with reduced HDL-cholesterol (HDL-C) levels. ABCA1 may also be important in regulating β-cell cholesterol homeostasis a...

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Foilsithe in:Diabetes
Main Authors: Rickels, Michael R., Goeser, Eugen S., Fuller, Carissa, Lord, Christine, Bowler, Anne M., Doliba, Nicolai M., Hegele, Robert A., Cuchel, Marina
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2015
Ábhair:
Pathophysiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274805/
https://ncbi.nlm.nih.gov/pubmed/25125487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0436
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