Multiserotype Protection of Mice against Pneumococcal Colonization of the Nasopharynx and Middle Ear by Killed Nonencapsulated Cells Given Intranasally with a Nontoxic Adjuvant

Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic adjuvants tested, the cholera toxin B sub...

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Detalhes bibliográficos
Main Authors: Malley, Richard, Morse, Sarah C., Leite, Luciana C. C., Areas, Ana Paula Mattos, Ho, Paulo Lee, Kubrusly, Flavia S., Almeida, Igor C., Anderson, Porter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC427453/
https://ncbi.nlm.nih.gov/pubmed/15213177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.7.4290-4292.2004
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