Dual Role of Interleukin-4 (IL-4) in Pulmonary Paracoccidioidomycosis: Endogenous IL-4 Can Induce Protection or Exacerbation of Disease Depending on the Host Genetic Pattern

Resistance to paracoccidioidomycosis, the most important endemic mycosis in Latin America, is thought to be primarily mediated by cellular immunity and the production of gamma interferon. To assess the role of interleukin-4 (IL-4), a Th2 cytokine, pulmonary paracoccidioidomycosis in IL-4-depleted su...

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Main Authors: Arruda, Celina, Valente-Ferreira, Rita C., Pina, Adriana, Kashino, Suely S., Fazioli, Raquel A., Vaz, Celidéia A. C., Franco, Marcello F., Keller, Alexandre C., Calich, Vera L. G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC427439/
https://ncbi.nlm.nih.gov/pubmed/15213137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.7.3932-3940.2004
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