Absence of Interleukin-4 Determines Less Severe Pulmonary Paracoccidioidomycosis Associated with Impaired Th2 Response

Host resistance to paracoccidiodomycosis, the main deep mycosis in Latin America, is mainly due to cellular immunity and gamma interferon (IFN-γ) production. To assess the role of interleukin-4 (IL-4), a Th2-inducing cytokine, pulmonary paracoccidioidomycosis was studied in IL-4-deficient (IL-4(−/−)...

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Autori principali: Pina, Adriana, Valente-Ferreira, Rita C., Molinari-Madlum, Eugênia E. W., Vaz, Celidéia A. C., Keller, Alexandre C., Calich, Vera L. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Fungal and Parasitic Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC375147/
https://ncbi.nlm.nih.gov/pubmed/15039362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.4.2369-2378.2004
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