Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma

PURPOSE: Medullary thyroid carcinoma (MTC) is a manifestation of multiple endocrine neoplasia type 2 (MEN2) syndromes caused by germline, activating mutations in the RET proto-oncogene. Vandetanib, a VEGF and EGF receptor inhibitor, blocks RET tyrosine kinase activity and is active in adults with he...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Fox, Elizabeth, Widemann, Brigitte C., Chuk, Meredith K., Marcus, Leigh, Aikin, Alberta, Whitcomb, Patricia O., Merino, Maria J., Lodish, Maya, Dombi, Eva, Steinberg, Seth M., Wells, Samuel A., Balis, Frank M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274128/
https://ncbi.nlm.nih.gov/pubmed/23766359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0071
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