Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts

Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types. S1P lyase is the enzyme that irreversibly cleaves S1P and thereby constitutes the ultimate step in sphingolipid catabolism. It has been reported pre...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Ihlefeld, Katja, Vienken, Hans, Claas, Ralf Frederik, Blankenbach, Kira, Rudowski, Agnes, ter Braak, Michael, Koch, Alexander, Van Veldhoven, Paul P., Pfeilschifter, Josef, Meyer zu Heringdorf, Dagmar
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274072/
https://ncbi.nlm.nih.gov/pubmed/25385827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M052761
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