Evaluation of the “Steal” Phenomenon on the Efficacy of Hypoxia Activated Prodrug TH-302 in Pancreatic Cancer

Pancreatic ductal adenocarcinomas are desmoplastic and hypoxic, both of which are associated with poor prognosis. Hypoxia-activated prodrugs (HAPs) are specifically activated in hypoxic environments to release cytotoxic or cytostatic effectors. TH-302 is a HAP that is currently being evaluated in a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bailey, Kate M., Cornnell, Heather H., Ibrahim-Hashim, Arig, Wojtkowiak, Jonathan W., Hart, Charles P., Zhang, Xiaomeng, Leos, Rafael, Martinez, Gary V., Baker, Amanda F., Gillies, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273999/
https://ncbi.nlm.nih.gov/pubmed/25532146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113586
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