Olmesartan Decreased Levels of IL-1β and TNF-α, Down-Regulated MMP-2, MMP-9, COX-2, RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model

Methotrexate (MTX) is a pro-oxidant compound that depletes dihydrofolate pools and is widely used in the treatment of leukaemia and other malignancies. The efficacy of methotrexate is often limited by mucositis and intestinal injury, which are major causes of morbidity in children and adults. The ai...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Araújo Júnior, Raimundo Fernandes, da Silva Reinaldo, Maria Patrícia Oliveira, Brito, Gerly Anne de Castro, Cavalcanti, Pedro de França, Freire, Marco Aurélio de Moura, de Medeiros, Caroline Addison Xavier, de Araújo, Aurigena Antunes
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273993/
https://ncbi.nlm.nih.gov/pubmed/25531650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114923
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