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Recoding Aminoacyl-tRNA Synthetases for Synthetic Biology by Rational Protein-RNA Engineering

[Image: see text] We have taken a rational approach to redesigning the amino acid binding and aminoacyl–tRNA pairing specificities of bacterial glutaminyl–tRNA synthetase. The four-stage engineering incorporates generalizable design principles and improves the pairing efficiency of noncognate glutam...

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書誌詳細
出版年:ACS Chem Biol
主要な著者: Hadd, Andrew, Perona, John J.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273986/
https://ncbi.nlm.nih.gov/pubmed/25310879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5006596
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