Mutation Profiling and Microsatellite Instability in Stage II and III Colon Cancer: An Assessment of Their Prognostic and Oxaliplatin Predictive Value

PURPOSE: The purpose of this study was to examine the prognostic and oxaliplatin predictive value of mismatch repair (MMR) status and common hot spot mutations, which we previously identified in stage II and III colon cancer. EXPERIMENTAL DESIGN: Mutations in BRAF, KRAS, NRAS, MET, and PIK3CA were p...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Gavin, Patrick G., Colangelo, Linda H., Fumagalli, Debora, Tanaka, Noriko, Remillard, Matthew Y., Yothers, Greg, Kim, Chungyeul, Taniyama, Yusuke, Kim, Seung Il, Choi, Hyun Joo, Blackmon, Nicole L., Lipchik, Corey, Petrelli, Nicholas J., O'Connell, Michael J., Wolmark, Norman, Paik, Soonmyung, Pogue-Geile, Kay L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273673/
https://ncbi.nlm.nih.gov/pubmed/23045248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0605
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