Mutation Profiling and Microsatellite Instability in Stage II and III Colon Cancer: An Assessment of Their Prognostic and Oxaliplatin Predictive Value

PURPOSE: The purpose of this study was to examine the prognostic and oxaliplatin predictive value of mismatch repair (MMR) status and common hot spot mutations, which we previously identified in stage II and III colon cancer. EXPERIMENTAL DESIGN: Mutations in BRAF, KRAS, NRAS, MET, and PIK3CA were p...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Gavin, Patrick G., Colangelo, Linda H., Fumagalli, Debora, Tanaka, Noriko, Remillard, Matthew Y., Yothers, Greg, Kim, Chungyeul, Taniyama, Yusuke, Kim, Seung Il, Choi, Hyun Joo, Blackmon, Nicole L., Lipchik, Corey, Petrelli, Nicholas J., O'Connell, Michael J., Wolmark, Norman, Paik, Soonmyung, Pogue-Geile, Kay L.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273673/
https://ncbi.nlm.nih.gov/pubmed/23045248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0605
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