Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. Using genome-wide association single-nucleotide polymorphism data from the Glaucoma Genes and Environment study and National Eye Institute Glaucoma Human Genetics Collaboration comprising 3,108 cases and 3,430 controls, we...

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Udgivet i:Hum Genet
Main Authors: Cooke Bailey, Jessica N., Yaspan, Brian L., Pasquale, Louis R., Hauser, Michael A., Kang, Jae H., Loomis, Stephanie J., Brilliant, Murray, Budenz, Donald L., Christen, William G., Fingert, John, Gaasterland, Douglas, Gaasterland, Terry, Kraft, Peter, Lee, Richard K., Lichter, Paul R., Liu, Yutao, McCarty, Catherine A., Moroi, Sayoko E., Richards, Julia E., Realini, Tony, Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Vollrath, Douglas, Wollstein, Gadi, Zack, Donald J., Zhang, Kang, Pericak-Vance, Margaret A., Allingham, R. Rand, Weinreb, Robert N., Haines, Jonathan L., Wiggs, Janey L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273559/
https://ncbi.nlm.nih.gov/pubmed/25037249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-014-1468-7
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