Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility

Genome-wide association studies have found variation within the complement factor H gene family links to host susceptibility to meningococcal disease caused by infection with Neisseria meningitidis (Davila et al., 2010). Mechanistic insights have been challenging since variation within this locus is...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Caesar, Joseph JE, Lavender, Hayley, Ward, Philip N, Exley, Rachel M, Eaton, Jack, Chittock, Emily, Malik, Talat H, Goiecoechea De Jorge, Elena, Pickering, Matthew C, Tang, Christoph M, Lea, Susan M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273445/
https://ncbi.nlm.nih.gov/pubmed/25534642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04008
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