A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

A highly efficacious pre-erythrocytic stage vaccine would be an important tool for the control and elimination of malaria but is currently unavailable. High-level protection in humans can be achieved by experimental immunization with Plasmodium falciparum sporozoites attenuated by radiation or under...

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Udgivet i:eLife
Main Authors: van Schaijk, Ben C L, Ploemen, Ivo H J, Annoura, Takeshi, Vos, Martijn W, Foquet, Lander, van Gemert, Geert-Jan, Chevalley-Maurel, Severine, van de Vegte-Bolmer, Marga, Sajid, Mohammed, Franetich, Jean-Francois, Lorthiois, Audrey, Leroux-Roels, Geert, Meuleman, Philip, Hermsen, Cornelius C, Mazier, Dominique, Hoffman, Stephen L, Janse, Chris J, Khan, Shahid M, Sauerwein, Robert W
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2014
Fag:
Human Biology and Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273440/
https://ncbi.nlm.nih.gov/pubmed/25407681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03582
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