Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

Chemokines and their receptors regulate cell migration during development, immune system function, and in inflammatory diseases, making them important therapeutic targets. Nevertheless, the structural basis of receptor:chemokine interaction is poorly understood. Adding to the complexity of the probl...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kufareva, Irina, Stephens, Bryan S., Holden, Lauren G., Qin, Ling, Zhao, Chunxia, Kawamura, Tetsuya, Abagyan, Ruben, Handel, Tracy M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273337/
https://ncbi.nlm.nih.gov/pubmed/25468967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417037111
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