Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness. In contrast to the autosomal dominant for...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Miao, D’Aniello, Cristina, Verkerk, Arie O., Wrobel, Eva, Frank, Stefan, Ward-van Oostwaard, Dorien, Piccini, Ilaria, Freund, Christian, Rao, Jyoti, Seebohm, Guiscard, Atsma, Douwe E., Schulze-Bahr, Eric, Mummery, Christine L., Greber, Boris, Bellin, Milena
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273331/
https://ncbi.nlm.nih.gov/pubmed/25453094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419553111
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