Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

HVCN1 (Hydrogen voltage-gated channel 1) is the only mammalian voltage-gated proton channel. In human B lymphocytes, HVCN1 associates with the B-cell receptor (BCR) and is required for optimal BCR signaling and redox control. HVCN1 is expressed in malignant B cells that rely on BCR signaling, such a...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hondares, Elayne, Brown, Mark Adrian, Musset, Boris, Morgan, Deri, Cherny, Vladimir V., Taubert, Christina, Bhamrah, Mandeep K., Coe, David, Marelli-Berg, Federica, Gribben, John G., Dyer, Martin J. S., DeCoursey, Thomas E., Capasso, Melania
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273330/
https://ncbi.nlm.nih.gov/pubmed/25425665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411390111
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