Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

AIM: To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype (SASP). METHODS: Hydrogen peroxide treatment was used to induce senescence in the human HepG2 hepatocyte cell line. Senescence was confirmed by cytochemical staining for a panel of...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Irvine, Katharine M, Skoien, Richard, Bokil, Nilesh J, Melino, Michelle, Thomas, Gethin P, Loo, Dorothy, Gabrielli, Brian, Hill, Michelle M, Sweet, Matthew J, Clouston, Andrew D, Powell, Elizabeth E
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273135/
https://ncbi.nlm.nih.gov/pubmed/25548483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i47.17851
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