A Simple and Rapid Method Based on Liquid Chromatography-Tandem Mass Spectrometry for the Measurement of α-L-Iduronidase Activity in Dried Blood Spots: An Application to Mucopolysaccharidosis I (Hurler) Screening

BACKGROUND: We developed an analytical method to measure α-L-iduronidase (IDUA) activity in dried blood spots. This was achieved by using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with electrospray ionization in the positive ion mode. METHODS: Chromatographic separation wa...

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Bibliographic Details
Published in:Ann Lab Med
Main Authors: Yang, Jeong Soo, Min, Hye Kyeong, Oh, Hyeon Ju, Woo, Hye In, Lee, Soo-Youn, Kim, Jong-Won, Song, Junghan, Park, Hyung-Doo
Format: Artigo
Language:Inglês
Published: The Korean Society for Laboratory Medicine 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272964/
https://ncbi.nlm.nih.gov/pubmed/25553279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3343/alm.2015.35.1.41
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