Use of Adaptive Laboratory Evolution To Discover Key Mutations Enabling Rapid Growth of Escherichia coli K-12 MG1655 on Glucose Minimal Medium

Adaptive laboratory evolution (ALE) has emerged as an effective tool for scientific discovery and addressing biotechnological needs. Much of ALE's utility is derived from reproducibly obtained fitness increases. Identifying causal genetic changes and their combinatorial effects is challenging a...

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Detalles Bibliográficos
Publicado en:Appl Environ Microbiol
Autores principales: LaCroix, Ryan A., Sandberg, Troy E., O'Brien, Edward J., Utrilla, Jose, Ebrahim, Ali, Guzman, Gabriela I., Szubin, Richard, Palsson, Bernhard O., Feist, Adam M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Evolutionary and Genomic Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272732/
https://ncbi.nlm.nih.gov/pubmed/25304508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02246-14
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