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The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer

Mod5 is the yeast tRNA isopentenyl transferase, an enzyme that is conserved from bacteria to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, and the yeast enzyme has been shown capable of forming heritable, amyloid-like aggregates that confer a selective adva...

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Detalhes bibliográficos
Publicado no:Gene
Main Authors: Smaldino, P.J., Read, D.F., Pratt-Hyatt, M., Hopper, A.K., Engelke, D.R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272631/
https://ncbi.nlm.nih.gov/pubmed/25261850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2014.09.049
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