NF-κB Signaling Is Required for XBP1 (Unspliced and Spliced)-Mediated Effects on Antiestrogen Responsiveness and Cell Fate Decisions in Breast Cancer

Antiestrogen therapy induces the unfolded protein response (UPR) in estrogen receptor-positive (ER(+)) breast cancer. X-box binding protein 1 (XBP1), which exists in the transcriptionally inactive unspliced form [XBP1(U)] and the spliced active form [XBP1(S)], is a key UPR component mediating anties...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Hu, Rong, Warri, Anni, Jin, Lu, Zwart, Alan, Riggins, Rebecca B., Fang, Hong-Bin, Clarke, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272419/
https://ncbi.nlm.nih.gov/pubmed/25368386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00847-14
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