The Selective Antagonism of P2X(7) and P2Y(1) Receptors Prevents Synaptic Failure and Affects Cell Proliferation Induced by Oxygen and Glucose Deprivation in Rat Dentate Gyrus

Purinergic P2X and P2Y receptors are broadly expressed on both neurons and glial cells in the central nervous system (CNS), including dentate gyrus (DG). The aim of this research was to determine the synaptic and proliferative response of the DG to severe oxygen and glucose deprivation (OGD) in acut...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maraula, Giovanna, Lana, Daniele, Coppi, Elisabetta, Gentile, Francesca, Mello, Tommaso, Melani, Alessia, Galli, Andrea, Giovannini, Maria Grazia, Pedata, Felicita, Pugliese, Anna Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272279/
https://ncbi.nlm.nih.gov/pubmed/25526634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115273
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