Maintenance of Leukemia-Initiating Cells Is Regulated by the CDK Inhibitor Inca1

Functional differences between healthy progenitor and cancer initiating cells may provide unique opportunities for targeted therapy approaches. Hematopoietic stem cells are tightly controlled by a network of CDK inhibitors that govern proliferation and prevent stem cell exhaustion. Loss of Inca1 led...

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Pubblicato in:PLoS One
Autori principali: Bäumer, Nicole, Bäumer, Sebastian, Berkenfeld, Frank, Stehling, Martin, Köhler, Gabriele, Berdel, Wolfgang E., Müller-Tidow, Carsten, Tschanter, Petra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272264/
https://ncbi.nlm.nih.gov/pubmed/25525809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115578
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