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Maintenance of Leukemia-Initiating Cells Is Regulated by the CDK Inhibitor Inca1

Functional differences between healthy progenitor and cancer initiating cells may provide unique opportunities for targeted therapy approaches. Hematopoietic stem cells are tightly controlled by a network of CDK inhibitors that govern proliferation and prevent stem cell exhaustion. Loss of Inca1 led...

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Publicat a:PLoS One
Autors principals: Bäumer, Nicole, Bäumer, Sebastian, Berkenfeld, Frank, Stehling, Martin, Köhler, Gabriele, Berdel, Wolfgang E., Müller-Tidow, Carsten, Tschanter, Petra
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272264/
https://ncbi.nlm.nih.gov/pubmed/25525809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115578
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