Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

De novo copy-number variants (CNVs) can cause neuropsychiatric disease, but the degree to which they occur somatically, and during development, is unknown. Single-cell whole-genome sequencing (WGS) in >200 single cells, including >160 neurons from three normal and two pathological human brains...

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發表在:Cell Rep
Main Authors: Cai, Xuyu, Evrony, Gilad D., Lehmann, Hillel S., Elhosary, Princess C., Mehta, Bhaven K., Poduri, Annapurna, Walsh, Christopher A.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272008/
https://ncbi.nlm.nih.gov/pubmed/25159146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.043
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