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A Randomized, Placebo-Controlled, Multicenter, Biomarker-Selected, Phase 2 Study of Apricoxib in Combination with Erlotinib in Patients with Advanced Non–Small-Cell Lung Cancer

Cyclooxygenase-2 (COX-2) overexpression is associated with a poor prognosis in non–small-cell lung cancer (NSCLC) and may promote resistance to epidermal growth factor receptor inhibitors. This randomized phase 2 trial evaluated apricoxib, a novel COX-2 inhibitor, in combination with erlotinib in bi...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Gitlitz, Barbara J., Bernstein, Eric, Santos, Edgardo S., Otterson, Greg A., Milne, Ginger, Syto, Mary, Burrows, Francis, Zaknoen, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271824/
https://ncbi.nlm.nih.gov/pubmed/24736085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000082
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