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Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera Toxin

Epidermal growth factor (EGF) stimulates both DNA and RNA synthesis in contact-inhibited human fibroblasts. Stimulation of DNA synthesis is observed at concentrations as low as 3 pM, is half-maximal at 70 pM, and is maximal at 300 pM EGF. The action of EGF is similar to that of fetal-calf serum, but...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hollenberg, Morley D., Cuatrecasas, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1973
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC427148/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4355377/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.10.2964
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