Cardiac Myocyte-Specific AHR Activation Phenocopies TCDD-Induced Toxicity in Zebrafish

Exposure of zebrafish embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. AHR is found in the heart; however, AHR activation by TCDD is not confined to the heart and occurs throughout th...

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Udgivet i:Toxicol Sci
Main Authors: Lanham, Kevin A., Plavicki, Jessica, Peterson, Richard E., Heideman, Warren
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Dioxin and Arylhydrocarbon Receptor Actions in Zebrafish
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271120/
https://ncbi.nlm.nih.gov/pubmed/25037585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu111
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