Most common ‘sporadic’ cancers have a significant germline genetic component

Common cancers have been demarcated into ‘hereditary’ or ‘sporadic’ (‘non-hereditary’) types historically. Such distinctions initially arose from work identifying rare, highly penetrant germline mutations causing ‘hereditary’ cancer. While rare mutations are important in particular families, most ca...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Lu, Yi, Ek, Weronica E., Whiteman, David, Vaughan, Thomas L., Spurdle, Amanda B., Easton, Douglas F., Pharoah, Paul D., Thompson, Deborah J., Dunning, Alison M., Hayward, Nicholas K., Chenevix-Trench, Georgia, Macgregor, Stuart
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Association Studies Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271103/
https://ncbi.nlm.nih.gov/pubmed/24943595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu312
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