HCV 3a Core Protein Increases Lipid Droplet Cholesteryl Ester Content via a Mechanism Dependent on Sphingolipid Biosynthesis

Hepatitis C virus (HCV) infected patients often develop steatosis and the HCV core protein alone can induce this phenomenon. To gain new insights into the pathways leading to steatosis, we performed lipidomic profiling of HCV core protein expressing-Huh-7 cells and also assessed the lipid profile of...

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Veröffentlicht in:PLoS One
Hauptverfasser: Loizides-Mangold, Ursula, Clément, Sophie, Alfonso-Garcia, Alba, Branche, Emilie, Conzelmann, Stéphanie, Parisot, Clotilde, Potma, Eric O., Riezman, Howard, Negro, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270764/
https://ncbi.nlm.nih.gov/pubmed/25522003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115309
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