HCV 3a Core Protein Increases Lipid Droplet Cholesteryl Ester Content via a Mechanism Dependent on Sphingolipid Biosynthesis

Hepatitis C virus (HCV) infected patients often develop steatosis and the HCV core protein alone can induce this phenomenon. To gain new insights into the pathways leading to steatosis, we performed lipidomic profiling of HCV core protein expressing-Huh-7 cells and also assessed the lipid profile of...

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Publicat a:PLoS One
Autors principals: Loizides-Mangold, Ursula, Clément, Sophie, Alfonso-Garcia, Alba, Branche, Emilie, Conzelmann, Stéphanie, Parisot, Clotilde, Potma, Eric O., Riezman, Howard, Negro, Francesco
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270764/
https://ncbi.nlm.nih.gov/pubmed/25522003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115309
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