HCV 3a Core Protein Increases Lipid Droplet Cholesteryl Ester Content via a Mechanism Dependent on Sphingolipid Biosynthesis

Hepatitis C virus (HCV) infected patients often develop steatosis and the HCV core protein alone can induce this phenomenon. To gain new insights into the pathways leading to steatosis, we performed lipidomic profiling of HCV core protein expressing-Huh-7 cells and also assessed the lipid profile of...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Loizides-Mangold, Ursula, Clément, Sophie, Alfonso-Garcia, Alba, Branche, Emilie, Conzelmann, Stéphanie, Parisot, Clotilde, Potma, Eric O., Riezman, Howard, Negro, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270764/
https://ncbi.nlm.nih.gov/pubmed/25522003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115309
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