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Cyclic Adenosine Monophosphate Receptor: Loss of cAMP-Dependent DNA Binding Activity after Proteolysis in the Presence of Cyclic Adenosine Monophosphate

The cAMP receptor requires cAMP for DNA binding at pH 8.0 but shows cAMP-independent DNA binding at pH 6.0. Incubation of the cAMP receptor with proteolytic enzymes in the presence of cAMP results in loss of DNA-binding ability at pH 8, while it is still able to bind cAMP and DNA at pH 6. Incubation...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Krakow, Joseph S., Pastan, Ira
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1973
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC427049/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4354854/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.9.2529
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