Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well as in other key components of the pathway, cause a spectr...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Ramsbottom, Simon A., Sharma, Vipul, Rhee, Hong Jun, Eley, Lorraine, Phillips, Helen M., Rigby, Hannah F., Dean, Charlotte, Chaudhry, Bill, Henderson, Deborah J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270488/
https://ncbi.nlm.nih.gov/pubmed/25521757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004871
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