Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well as in other key components of the pathway, cause a spectr...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Autores principales: Ramsbottom, Simon A., Sharma, Vipul, Rhee, Hong Jun, Eley, Lorraine, Phillips, Helen M., Rigby, Hannah F., Dean, Charlotte, Chaudhry, Bill, Henderson, Deborah J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270488/
https://ncbi.nlm.nih.gov/pubmed/25521757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004871
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