Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis

The most polymorphic gene family in P. falciparum is the ∼60 var genes distributed across parasite chromosomes, both in the subtelomeres and in internal regions. They encode hypervariable surface proteins known as P. falciparum erythrocyte membrane protein 1 (PfEMP1) that are critical for pathogenes...

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Udgivet i:PLoS Genet
Main Authors: Claessens, Antoine, Hamilton, William L., Kekre, Mihir, Otto, Thomas D., Faizullabhoy, Adnan, Rayner, Julian C., Kwiatkowski, Dominic
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270465/
https://ncbi.nlm.nih.gov/pubmed/25521112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004812
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