Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model

Previous clinical studies have demonstrated that endotoxin/toll-like receptor 4 (TLR4) signaling is critical in the inflammatory pathways associated with non-alcoholic steatohepatitis (NASH). In human and animal studies, NASH was associated with portal lipopolysaccharide (LPS) and the plasma LPS lev...

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Veröffentlicht in:Mol Med Rep
Hauptverfasser: DOUHARA, AKITOSHI, MORIYA, KEI, YOSHIJI, HITOSHI, NOGUCHI, RYUICHI, NAMISAKI, TADASHI, KITADE, MITSUTERU, KAJI, KOSUKE, AIHARA, YOSUKE, NISHIMURA, NORIHISA, TAKEDA, KOSUKE, OKURA, YASUSHI, KAWARATANI, HIDETO, FUKUI, HIROSHI
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270343/
https://ncbi.nlm.nih.gov/pubmed/25421042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2014.2995
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